The cees dekker Diaries
The cees dekker Diaries
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests include things like:
You frequently get involved in conversations about science and faith. You may have also composed several textbooks on the subject. Don’t you believe eventually we will know all the things and that God’s job is going to be over?
[Laughs] ‘It absolutely was unquestionably an awesome possibility! At enough time, I used to be effectively conscious that it could go Incorrect and that I could become much less thriving, but I just disregarded that. Curiosity has constantly been my strongest driving power. And fortuitously it all labored out.’
Our function was swiftly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors created from solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initial at any time examine from the dynamics DNA supercoils and the discovery of supercoil hopping
The coiled-coil on the human Rad50 DNA fix protein consists of specific segments of amplified overall flexibility
Given that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling research of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Just lately his analysis has focused on finding out cell division with bacteria on chip, though his supreme curiosity is in the way of noticing synthetic cells.
2000, discovery that nanotubes can carry remarkable substantial current densities; settled the controversial difficulty of electronic transportation as a https://www.ceesdekker.net result of DNA molecules by measurements of insulating behavior at The only molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
Knowing basic processes regulating the spatial and dynamic organisation in the DNA in Dwell cells.
Dekker started out his study on one carbon nanotubes in 1993 when he put in place a brand new line of research to review electrical transport by solitary organic molecules involving nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in the collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography methods were being accustomed to show that these nanotubes are quantum wires at The one-molecule level, with remarkable physical Attributes.
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his investigation has focused on finding out chromatin structure and cell division with bacteria on chip, when he can also be aiming to in the end Make synthetic cells from The underside up.
Nanoscientist Cees Dekker is definitely an amiable and flamboyant man who seems Substantially youthful compared to 62 decades he essentially is – stylish glasses, psychedelic shirt, partaking smile – although not a single to squander time. He can take his time, but no more than necessary.
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Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in gray, the rim on the pore is highlighted in red, plus a 3D rendering from the movement of the DNA rod is shown.